For people with knee osteoarthritis, oral collagen supplements might act as a mild pain reliever and improve joint function. Since i drank my peptides in the morning with my coffee (around 9:30), i found myself full until lunchtime. Pin on Medical Trials into collagen’s role in treating osteoarthritis give mixed results. How long does it take for collagen to work for joint pain . But it will take a little longer before you can see and feel results. Collagen supplements may reduce wrinkles and increase hydration. How long does it take for collagen to work on joints : In some studies that focused on more serious issues such as chronic joint pain or liver rehabilitation, it took up to six months to see the full impact of collagen supplementation. How long does it take for collagen supplements to work collagen supplements are quickly absorbed into your bloodstream and within an hour your body will begin using them to regenerate collagen. Your body will begin using them to rebu...